Max Ink has made some videos promoting his comic Blink. Here are a few Blink videos for your enjoyment:
Following suit, but playing at a more aggressive/humorous spin, I've made some promotional videos for Symphony of the Universe.
Large companies like MARVEL and DC have been taking full advantage of cross marketing their comics with movies, TV shows, and toys. I see no reason that indie creators shouldn't promote with youtube, podcasts, and all that the internet has to offer. It's just one more way of getting comics out of the back stockroom or comic con and out into the public eye.
Enjoy the videos!